Table 1. Lung, heart, liver and kidney weight relative to body weight, in IGF-1R+/+ and IGF-1R−/− embryos.
| Developmental stage | E14.5 | E17.5 | E19.5 | |||
| Genotype | IGF-1R+/+ | IGF-1R−/− | IGF-1R+/+ | IGF-1R−/− | IGF-1R+/+ | IGF-1R−/− |
| Body weight (mg) | 184.4±12.3 | 130.2±2.8* | 853.5±27.7 | 404.5±24.2*** | 1294.1±14.9 | 593.5±21.1*** |
| Lung (mg) | 3.26±0.10 | 1.58±0.03*** | 26.81±1.01 | 6.75±0.40*** | 40.76±1.57 | 10.73±0.82*** |
| Heart (mg) | 1.40±0.06 | 0.84±0.16** | 4.95±0.27 | 2.81±0.35*** | 9.80±0.35 | 4.55±0.33*** |
| Liver (mg) | 12.30±0.89 | 9.62±0.83* | 47.69±1.64 | 27.30±1.15*** | 73.49±3.30 | 38.52±1.95** |
| Kidney (mg) | 0.50±0.05a | ND | 7.50±0.27 | 3.11±0.34*** | 13.78±0.18 | 7.30±0.53*** |
| Lung/BW (%) | 1.49±0.12 | 1.22±0.04 | 3.14±0.03 | 1.68±0.08*** | 3.15±0.10 | 1.90±0.13*** |
| Heart/BW (%) | 0.78±0.05 | 0.74±0.06 | 0.58±0.02 | 0.68±0.07 | 0.76±0.03 | 0.80±0.04 |
| Liver/BW (%) | 6.26±0.23 | 6.35±0.56 | 5.60±0.13 | 6.86±0.40** | 5.86±0.17 | 6.84±0.30* |
| Kidney/BW (%) | 0.25±0.02a | ND | 0.88±0.02 | 0.77±0.07 | 1.07±0.02 | 1.24±0.07* |
| N | 7 | 6 | 13 | 7 | 8 | 6 |
Values are mean ± SEM. * P<0.05; ** P<0.01; *** P<0.001 compared with IGF-1R+/+ mice. Student’s t-test.
a
n = 5; BW, body weight; ND, not determined.