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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Brain Behav Immun. 2012 Aug 10;26(8):1256–1264. doi: 10.1016/j.bbi.2012.08.003

Figure 1. Chronic morphine pretreatment potentiates allodynia from hind paw inflammation.

Figure 1

Rats were dosed with morphine (solid) or vehicle (open) at 5mg/kg b.i.d. for 5 days. Two days after the conclusion of dosing, CFA (square) or saline (circle) was injected into the hind paw, and mechanical allodynia characterized in both the (A) ipsilateral and (B) contralateral paws. Significant potentiation of mechanical allodynia by morphine was observed in the ipsilateral and contralateral hind paw. BL denotes baseline pre morphine/saline dosing. Data presented as mean ± SEM (n=6/group). *P<0.05 between vehicle+CFA and saline+saline, $ P<0.05 between morphine+CFA and saline +saline for each time point.