. Author manuscript; available in PMC: 2013 Dec 1.

Published in final edited form as: Parasitol Res. 2012 Jul 5;111(6):2473–2477. doi: 10.1007/s00436-012-3019-2

Table 1.

Effect of echinomycin A and tirandamycin on the growth of E. histolytica trophozoites (EIC₅₀ values for 48 and 72 hrs are also shown)

Concentration	No. trophozoites x 10⁶ (% inhibition in respect to controls)
	Echinomycin A		Tirandamycin		Metronidazole

	48 h	72 h	48 h	72 h	48 h	72 h
	E.histolytica HM1:1MSS Control	3.83 (NA)	6.33 (NA)	3.83 (NA)	6.33 (NA)	3.83 (NA)	6.33 (NA)
E.histolytica Col Control	3.67 (NA)	6.17 (NA)	3.67 (NA)	6.17 (NA)	3.67 (NA)	6.17 (NA)
E.histolytica HM1:1MSS 35.6 μM^a	------	------	------	3.09 (50)^b	------	------
E.histolytica Col 46.3 μM^a	------	------	------	3.16 (50)^b	------	------
E.histolytica HM1:1MSS 42.2 μM^a	------	3.09 (50) ^b	------	------	------	------
E.histolytica Col 44.3 μM ^a	------	3.16 (50) ^b	------	------	------	------
E.histolytica HM1:1MSS 50 μM	3.75 (2.1)	2.25 (64.5)	3.0 (21.7)	1.5 (76.3)	ND	ND
E.histolytica Col 50 μM	3.25 (11.4 )	2.25 (63.5)	3.0 (18.3)	2.25 (63.5)	ND	ND
E.histolytica HM1:1MSS 60 μM	3.0 (21.7)	1.83 (71.1)	2.75 (28.2)	1.0 (84.2)	ND	ND
E.histolytica Col 60 μM	3.5 (4.6)	2 (67.6)	2.50 (31.9)	2.17 (64.8)	ND	ND
E.histolytica HM1:1MSS 20 μM	ND	ND	ND	ND	1.0 (73.9)	0.5 (92.1)
E.histolytica Col 20 μM	ND	ND	ND	ND	0.83 (77.4)	0.5 (91.9)

NA, not applicable

EIC₅₀, estimated inhibitory concentrations of antibiotics required to inhibit 50% amoebic growth

Estimated No. of trophozoites × 10 ⁶ killed by EIC₅₀