Table 3.
Association of kidney function with frailty prevalence in the Seattle Kidney Study
| Frail Cases (no./no. at risk) | Model 1 (n=336) | Model 2 (n=336) | |
|---|---|---|---|
| eGFRcys | |||
| ≥60 ml/min/1.73m2 | 8/99 | 1.0 (reference) | 1.0 (reference) |
| 45–59 ml/min/1.73m2 | 6/74 | 1.3 (0.5–3.6) | 1.2 (0.4–3.3) |
| 30–44 ml/min/1.73m2 | 19/88 | 3.3 (1.5–7.4) | 2.8 (1.3–6.3) |
| <30 ml/min/1.73m2 | 14/75 | 2.6 (1.1–5.9) | 2.1 (1.0–4.7) |
| eGFRcys p-for-trend | 0.01 | 0.01 | |
| Age (per 10y older) | 0.9 (0.7–1.1) | 0.9 (0.8–1.2) | |
| Non-white race | 1.8 (1.1–3.1) | 1.9 (1.1–3.3) | |
| Female | 0.9 (0.5–1.6) | 1.2 (0.6–2.2) | |
| BMI (per 5-kg/m2 difference) | -- | 1.2 (1.0–1.4) | |
| Diabetes | -- | 1.4 (0.8–2.4) | |
| Any cardiovascular disease | -- | 1.0 (0.6–1.7) | |
| Log(CRP) | -- | 1.2 (0.9–1.5) |
Except where indicated, values shown are prevalence ratio (95% confidence interval). Model 1: estimated glomerular filtration rate, sex, age, race (white versus other). Model 2: Model 1 + BMI + Diabetes + Any cardiovascular disease (CVD) + Log C-reactive protein.
Abbreviations: BMI = body mass index; CRP, C-reactive protein; eGFRcys, estimated glomerular filtration rate calculated by the CKD-EPI equation incorporating nonstandardized cystatin C level, age, sex, and race.