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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: J Comp Neurol. 2013 Feb 1;521(2):312–325. doi: 10.1002/cne.23188

Figure 2.

Figure 2

Trigeminothalamic projection in dcc knockout mice traced with DiI labeling of PrV neurons. Axons did not cross the midline at E11 (A) and a bundle of axons repelled from the midline and turned caudally (B). Marked stalling of axons before reaching the midline was observed at E13 (C). At higher magnification axons are stalled, turning towards different directions away from the midline, thus no midline crossing was observed at E13 (D). Even at E15, axons failed to cross the midline (E) and few axons turned rostrally to reach ipsilateral thalamus (F). B, D and F are higher magnification views of areas boxed in A, C, and E. Double arrow headed lines indicate the midline. PrV: principal sensory nucleus. Scale bar is 200µm.