. Author manuscript; available in PMC: 2013 Jan 4.

Published in final edited form as: Amino Acids. 2012 Mar 10;44(1):129–142. doi: 10.1007/s00726-011-1209-3

Table 1.

Frequency of γ-glutamyl-ε-lysine crosslinks in detergent-insoluble protein fractions of AD brains

Tissue	Group	γ-glutamyl-ε-lysine per 10⁶ residues	Fold change	References
Cerebellum/cortex	Control	0.10 × 10³		(Kim et al. 1999)
Cerebellum/cortex	AD	3–5 × 10³	30–50	(Kim et al. 1999)
Occipital lobe	Control	~2.00		(Nemes et al. 2004)
Occipital lobe	AD	~2.00	1.00
Frontal Cortex	Control	~5.83
Frontal Cortex	AD	~21.7	~3.71
Hippocampus	Control	~8.33
Hippocampus	AD	~31.7	~3.80
Frontal Cortex	Control	~0.11		(Nemes et al. 2009)
Frontal Cortex	AD	~0.58	~5.14
Hippocampus	Control	~0.11
Hippocampus	AD	~0.42	~3.71