Table 2.

FXR involved in the regulation of bile acid and xenobiotics metabolism

Metabolism	Gene	Substrate	Regulation	Manner	Reference
phase 0	NTCP	Bile acids	Suppression	Indirect effect	[51]
	OATP1B1	Bile acid, xenobiotics	Suprression	Indirect effect	[147]
	OATP1B3	Bile acid, xenobiotics	Activation	Direct effect	[148]
Phase I	CYP3A4	Bile acid, xenobiotics	Activation	Direct and indirect effect	[77,149]
	CYP7A1	Cholesterol	Suprression	Indirect effect	[59]
	CYP8B1	Cholesterol	Suprression	Indirect effect	[68]
	CYP27A1	Cholesterol	Suprression	Indirect effect	[69]
Phase II	UGT1A1	Bile acid, xenobiotics	Activation	Direct effect	[92]
	UGT2B4	Bile acid, xenobiotics	Activation	Direct effect	[78]
	UGT2B7	Bile acid, xenobiotics	Suppression	Direct effect	[150]
	SULT1a1	Bile acid, xenobiotics	Activation	Direct effect	[92]
	SULT1a2	Bile acid, xenobiotics	Activation	Direct effect	[92]
	SULT2A1	Bile acid, xenobiotics	Activation	Direct effect	[80]
	GSTα3	xenobiotics	Activation	Direct effect	[92]
	GSTα4	xenobiotics	Activation	Direct effect	[92]
	GSTμ1	xenobiotics	Activation	Direct effect	[92]
	GSTμ3	xenobiotics	Activation	Direct effect	[92]
	BACS	Bile acid	Activation	Direct effect	[151]
	BAT	Bile acid	Activation	Direct and indirect effect	[151,152]
Phase III	BSEP	Bile acid	Activation	Direct effect	[86]
	MRP2	Bile acid, xenobiotics	Activation	Direct and indirect effect	[153]
	MDR3	PC	Activation	Direct effect	[91]
	OSTα	Bile acid	Activation	Direct effect	[33,34]
	OSTβ	Bile acid	Activation	Direct effect	[33,34]
	FABP6	Bile acid	Activation	Direct effect	[30]
	ASTB	Bile acid	Suppression	Indirect effect	[24]