Fig. 2.

Gene maps of GATA2 (a), PBX4 (b), and NYX (c), including the position of the probes used in the MIAMI analysis. The number of CpG (covalent addition of a methyl group to a cytosine residue followed by a guanine) islands and the CG percentages throughout the genomic regions of these genes are also indicated. GATA binding protein 2 (GATA2) maps to chromosome (Ch) 3 q21.3, pre-B-cell leukemia homeobox 4 (PBX4) maps to Ch19 p12, and nyctalopin (NYX) maps to Ch X p11.4. Filled squares indicate the position of the probes with significant changes to the methylation status in Th0s. Probe A_17_P02574948 for GATA2 recognizes the region 3.6 kb upstream of the transcription start site of this gene, which is within a CpG island. The probe A_17_P10909964 sequence in PBX4 is located within the first intron of this gene, and probe A_17_P11717994 for NYX maps to the region just upstream of the transcription start site