Table 1.
List of MutuDC line types currently available or in the process of being generated (“in progress”).
| MutuDC line | DC type | Origin (mouse) |
Insert (lentivirus) | Status (reference) | |
|---|---|---|---|---|---|
| Genotype | Background | ||||
| WT | CD8α+ | CD11c:LgT-transgenic and otherwise WT (Steiner et al., 2008) | C57BL6 | Available (Fuertes Marraco et al., 2011) | |
| 1IFNR−/− | CD8α+ | CD11c:LgT-Tg × Ifnar1(tm1.Agt) | C57BL6 | Available (Fuertes Marraco et al., 2011) | |
| TLR3−/− | CD8α+ | CD11c:LgT-Tg × Tlr3(tm1.Flv) | C57BL6 | Available (Fuertes Marraco et al., 2011) | |
| TLR9−/− | CD8α+ | CD11c:LgT-Tg × Tlr9(tm1.Aki) | C57BL6 | Available | |
| MAVS−/− | CD8α+ | CD11c:LgT-Tg × CARDIF604Siec | C57BL6 | Available (Fuertes Marraco et al., 2011) | |
| NOX2−/− | CD8α+ | CD11c:LgT-Tg × Cybb (tm1.Din) | C57BL6 | Available | |
| NIK−/− | CD8α+ | CD11c:LgT-Tg × Map3k14(aly) | C57BL6 | Available | |
| H-2g7 (NOD) | CD8α+ | CD11c:LgT-Tg × NOD (Shi.Ltj) back-cross | NOD | Available | |
| H-2d | CD8α+ | CD11c:LgT-Tg × Balb/c back-cross | BALB/c | In progress | |
| H-2k | CD8α+ | CD11c:LgT-Tg × C3H back-cross | C3H | In progress | |
| Kb−/− | CD8α+ | CD11c:LgT-Tg × H–2Kb (tm1) | C57BL6 | In progress | |
| IRF8−/− | CD8α− (CD11b+) | CD11c:LgT-Tg × Irf8(tm1.Hor) | C57BL6 | Available | |
| BATF3−/− | CD8α− | CD11c:LgT-Tg × Batf (tm1.1Kmm) | C57BL6 | In progress | |
| Langerin:Tg | CD8α+ | Langerin:LgT-Tg and otherwise WT | C57BL6 | In progress | |
| CD80/CD86−/− | CD8α+ | CD11c:LgT-Tg × CD80−/− × CD86−/− | C57BL6 | In progress | |
| Bim−/− | CD8α+ | CD11c:LgT-Tg × Bcl2l11(tm1.1Ast) | C57BL6 | Available | |
| Bid−/− | CD8α+ | CD11c:LgT-Tg × Bid (tm1.1Ast) | C57BL6 | In progress | |
| Noxa−/− | CD8α+ | CD11c:LgT-Tg × Pmaip1(tm1.1Ast) | C57BL6 | In progress | |
| Bim−/− Bid−/− | CD8α+ | CD11c:LgT-Tg × Bcl2l11(tm1.1Ast) × Bid (tm1.1Ast) | C57BL6 | In progress | |
| Bim−/− Noxa−/− | CD8α+ | CD11c:LgT-Tg × Bcl2l11(tm1.1Ast) × Pmaip1(tm1.1Ast) | C57BL6 | In progress | |
| Caspase-1−/− | CD8α+ | CD11c:LgT-Tg x Caspase-1−/− | C57BL6 | In progress | |
| IFNβ+ 1IFNR−/− | CD8α+ | CMV:IFNβ+; CD11c:LgT-Tg × Ifnar1(tm1.Agt) | C57BL6 | IFNβ (NM_010510) | Available |
| Luciferase+ | CD8α+ | CMV:Luciferase+; CD11c:LgT-Tg | C57BL6 | Luciferase (AB261982) | Available |
| Indo+ | CD8α+ | CMV:Indo+; CD11c:LgT-Tg | C57BL6 | IDO (NM_008324.1) | In progress |
| Arginase+ | CD8α+ | CMV:Arginase+; CD11c:LgT-Tg | C57BL6 | Arginase (NM_007482.2) | In progress |
| IL-10+ | CD8α+ | CMV:IL-10+; CD11c:LgT-Tg | C57BL6 | IL-10 (NM_010548.1) | In progress |
| latent TGFβ+ | CD8α+ | CMV:latentTGFβ+; CD11c:LgT-Tg | C57BL6 | latent TGFβ (NM_011577.1) | In progress |
| active TGFβ+ | CD8α+ | CMV:activeTGFβ+; CD11c:LgT-Tg | C57BL6 | active TGFβ (mutant Cys223 and 225; Fowlis et al., 1996) | In progress |
| Activin A+ | CD8α+ | CMV:ActivinA+; CD11c:LgT-Tg | C57BL6 | Activin A (NM_002192) | |
| CTLA-4+ | CD8α+ | CMV:CTLA-4+; CD11c:LgT-Tg | C57BL6 | CTLA-4 (NM_009843) | In progress |
| B7-H1/PDL1+ | CD8α+ | CMV:B7-H1+; CD11c:LgT-Tg | C57BL6 | B7-H1 (NM_021893) | In progress |
| B7-DC/PDL2+ | CD8α+ | CMV:B7-DC+; CD11c:LgT-Tg | C57BL6 | B7-DC (NM_021396) | In progress |
| IL-2+ | CD8α+ | CMV:IL-2+ CD11c:LgT-Tg | C57BL6 | Il-2 (NM 008366) | In progress |
| IL12+ | CD8α+ | CMV:IL-12+ α and β as single chain construct with linker; CD11c:LgT-Tg | C57BL6 | IL12α and β Fc (NM_001159424) (NM 008352) | In progress |
| IL35+ | CD8α+ | CMV:IL-12α and CMV:EBI3+ as single chain construct with linker; CD11c:LgT-Tg | C57BL6 | IL-12α and EBI3 (NM 015766) | In progress |
| IL-15+ | CD8α+ | CMV:IL-15+; CD11c:LgT-Tg | C57BL6 | IL-15 (NM 008357) | In progress |