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. 2012 Nov 7;3:190. doi: 10.3389/fphar.2012.00190

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Copyright © 2012 O’Malley, Dinan and Cryan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

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IL-6 modulates transepithelial current and resistance. (A) The histograms illustrates basal short circuit current (I_SC, μA cm², SD: n = 18, WKY: n = 9) and (B) transepithelial resistance (TER, Ω cm², SD: n = 17, WKY: n = 8) in distal colon segments from naïve Sprague Dawley (SD) and Wistar Kyoto (WKY) rats. (C) The histograms and representative trace shows the effect of basolaterally applied IL-6 (1 nM, measured 10 min after application) on basal I_SC (SD: n = 23, WKY: n = 9). (D) This histogram illustrates the change (Δ) in tissue resistance over the course of the experiment (60–90 min, SD: n = 18, WKY: n = 6). Values = mean ± SEM.* Indicates p < 0.05.