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. 2012 Nov 7;3:190. doi: 10.3389/fphar.2012.00190

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Copyright © 2012 O’Malley, Dinan and Cryan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

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IL-6 alters capsaicin-induced currents in Sprague Dawley (SD) and Wistar Kyoto (WKY) rat colons. (A) The representative traces illustrate the secretory (phase I) and anti-secretory (phase II) responses to capsaicin (1 μM) in control SD (gray line, n = 10) and WKY (black line, n = 10) distal colons. (B) The histogram illustrates the pooled data for changes in current (I_SC). (C) The traces are representative of capsaicin-evoked responses following exposure to IL-6 (1 nM) in SD (n = 11) and WKY (n = 7). (D) The pooled data are plotted in a histogram. Values = mean ± SEM. * indicates p < 0.05.