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Inhibition of the initiator caspase 9 (Panel A) and caspase 8 (Panel B) in LPA1/2 double KO MEF cells transduced with empty vector (open bars) or the human LPA2 GPCR (filled bars). GRI (10 μM), LPA (3 μM) and OTP (3 μM) were added to the cells 1 h after irradiation with 15 Gy and caspase activation was measured 5 h later. Bars represent the mean of at least three independent experiments. (*p < 0.05, **p < 0.01, ***p < 0.001).
Kiss et al.
