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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Biochim Biophys Acta. 2013 Jan;1831(1):117–125. doi: 10.1016/j.bbalip.2012.08.020

Figure 3.

Figure 3

Dose-response relationship of the inhibition of executioner caspases 3 and 7 by LPA, OTP and GRI in LPA1/2 double KO MEF cells transduced with empty vector (open symbols) or the human LPA2 GPCR (filled symbols). GRI significantly reduced caspase 3 and 7 activation significantly above 300 nM only in the LPA2 receptor-transduced cells, while the effect of LPA and OTP manifested in the vector-transduced cells as well. Data points represent the mean of at least three independent experiments. (* p < 0.05, ** p < 0.01, *** p < 0.001 compared to irradiated vehicle treated cells).

Kiss et al.