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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Biochim Biophys Acta. 2013 Jan;1831(1):117–125. doi: 10.1016/j.bbalip.2012.08.020

Figure 4.

Figure 4

Inhibition of radiation-induced DNA fragmentation (panel A), Bax translocation (panel B) and PARP-1 cleavage (panel C) by LPA, OTP, and GRI in LPA1/2 double KO MEF cells transduced with empty vector (open bars on panel A) or the human LPA2 GPCR (filled bars on panel A). The concentrations of the ligands in the DNA fragmentation experiments was: GRI (10 μM), LPA (3 μM), and OTP (3 μM). Note that GRI selectively protected LPA2-transduced MEF cells compared with LPA or OTP (Panel A, * p < 0.05, ** p < 0.01, *** p < 0.001). γ-irradiation induced cytosolic Bax depletion (Panel B) and PARP-1 cleavage (Panel C) were effectively reduced by 10 μM GRI. Bars and western blots shown are representative of three experiments.

Kiss et al.