Table 5.
Non-synonymous SNPs between C57BL6/J and FVB/NJ in Ath11
| Chromosome 10 position | Ref/FVB | dbSNP ID | MGP | Gene name, Ensembl gene ID and description | Trans. | Protein domain |
|---|---|---|---|---|---|---|
| 5016217 | G/C | None | 8 |
Syne1 ENSMUSG00000019769 Synaptic nuclear envelope 1 |
1/4 | Spectrin repeat |
| 5380387 | C/A | rs29315913 | 13 |
Esr1 ENSMUSG0000001976 Estrogen receptor 1 |
1/5 | Nuclear hormone receptor, ligand-binding, core |
| 5977100 | A/C | None | 16 |
Zbtb2 ENSMUSG00000075327 Zinc finger and BTB domain containing 2 |
2/2 | None |
| 6338741 | A/G | rs29378605 | 15 |
Mthfd1l ENSMUSG00000040675 Methylenetetrahydrofolate dehydrogenase (NAD P+ dependent) 1-like |
3/3 | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain |
| 6367833 | A/G | rs29320259 | 14 |
Mthfd1l ENSMUSG00000040675 Methylenetetrahydrofolate dehydrogenase (NAD P+ dependent) 1-like |
3/3 | Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain |
| 7309964 | T/C | rs29376214 | 6 |
Lrp11 ENSMUSG00000019796 Low density lipoprotein receptor-related protein 11 |
4/6 | Polycystic Kidney Disease(PKD) domain |
| 21108744 | A/G | rs49757404 | 12 |
Aldh8a1 ENSMUSG00000037542 Aldehyde dehydrogenase 8 family |
1/2 | Aldehyde dehydrogenase domain |
| 21787374 | C/T | rs47037014 | 8 |
4930444G20Rik ENSMUSG00000069712 RIKEN cDNA 4930444G20 gene |
1/1 | None |
| 21787451 | A/C | rs50088182 | 9 |
4930444G20Rik ENSMUSG00000069712 RIKEN cDNA 4930444G20 gene |
1/1 | None |
| 21864292 | C/T | rs49453000 | 8 |
E030030I06Rik ENSMUSG00000055657 RIKEN cDNA E030030I06 gene |
1/1 | None |
| 21868313 | T/C | None | 9 |
E030030I06Rik ENSMUSG00000055657 RIKEN cDNA E030030I06 gene |
1/1 | None |
| 21868315 | T/A | None | 9 |
E030030I06Rik ENSMUSG00000055657 RIKEN cDNA E030030I06 gene |
1/1 | None |
Wolfrum et al. [34] characterized two narrowed regions, 10a and 10b, within Ath11 containing 28 genes. This table describes additional non-synonymous SNPs discovered by sequencing of the FVB/NJ genome. Listed are the reference allele and FVB/NJ allele (Ref/FVB), the dbSNP ID (build 128) for sites previously identified as polymorphic in other mouse strains, and the number of strains in the Mouse Genomes Project (MGP) with the same allele as FVB/NJ. Also listed is the number of protein-coding transcripts (Trans.) affected and the protein domain involved. Gene and protein domain models were obtained from Ensembl version 64.