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. 2012 Jul 25;13(7):R65. doi: 10.1186/gb-2012-13-7-r65

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Copyright ©2012 Andersen et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Maternal genes are preferentially hypomethylated relative to zygotic or non-expressed genes. (a) Hypomethylated domain over the hoxa locus in embryos and ZF4 cells. (b) Venn diagram analysis of hypomethylated genes at pre-MBT, MBT and post-MBT stages. (c) Domains of high o/e CG ratios exhibit hypomethylation, exemplified in a 51-kb region of chromosome 11 in pre-MBT embryos. (d) Proportions of hypomethylated genes in developmental gene cohorts. ^a,b/a,c/b,cP < 10^-4within developmental stage (Fisher).