Table 1.
Total sizes of the six types of genomic regions derived from transcription factor binding data in the five cell lines
| Region type | GM12878 | H1-hESC | HeLa-S3 | Hep-G2 | K562 |
|---|---|---|---|---|---|
| Binding active regions (BARs) | 109 Mbp (3.5%) | 78.8 Mbp (2.6%) | 93.6 Mbp (3.0%) | 88.8 Mbp (2.9%) | 98.7 Mbp (3.2%) |
| Binding inactive regions (BIRs) | 1,390 Mbp (45%) | 1,200 Mbp (39%) | 1,330 Mbp (43%) | 401 Mbp (13%) | 1,010 Mbp (33%) |
| Promoter-proximal regulatory modules (PRMs) | 25.4 Mbp (0.82%) | 15.5 Mbp (0.50%) | 20.7 Mbp (0.67%) | 17.1 Mbp (0.55%) | 24.3 Mbp (0.79%) |
| Gene-distal regulatory modules (DRMs) | 24.6 Mbp (0.80%) | 18.2 Mbp (0.59%) | 25.3 Mbp (0.82%) | 21.1 Mbp (0.68%) | 22.0 Mbp (0.71%) |
| High occupancy of TF (HOT) regions (whole genome) | 25.9 Mbp (0.84%) | 26.4 Mbp (0.86%) | 25.6 Mbp (0.83%) | 26.3 Mbp (0.85%) | 26.6 Mbp (0.86%) |
| High occupancy of TF (HOT) regions (intergenic regions only) | 5.82 Mbp (0.19%) | 6.43 Mbp (0.21%) | 6.70 Mbp (0.22%) | 6.74 Mbp (0.22%) | 5.18 Mbp (0.17%) |
| Low occupancy of TF (LOT) regions (whole genome) | 24.7 Mbp (0.80%) | 23.5 Mbp (0.76%) | 22.8 Mbp (0.74%) | 23.8 Mbp (0.77%) | 24.2 Mbp (0.78%) |
| Low occupancy of TF (LOT) regions (intergenic regions only) | 10.7 Mbp (0.35%) | 11.0 Mbp (0.36%) | 10.1 Mbp (0.33%) | 10.7 Mbp (0.35%) | 12.4 Mbp (0.40%) |
Numbers in parentheses are the percentages of the whole human genome covered by the regions. Intergenic regions are defined as regions at least 10 kbp from any level 1 or level 2 gene defined in Gencode version 7.