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. 2012 Oct 3;13(10):R86. doi: 10.1186/gb-2012-13-10-r86

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Copyright ©2012 Tian et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Representative isoforms with PTMs beyond the N-terminal tail and with phosphorylation. (a) Intact H3 isoforms observed from second dimension WCX-HILIC analysis of H31 fraction as shown in Figure 1 (a). (b) Example tandem mass spectra for an isoform displaying modification beyond the histone tail (top) and a phosphorylated isoform (bottom). Insets show the corresponding parent ion spectra with precursor ions selected for fragmentation boxed. PTM, post-translation modification; WCX-HILIC, weak cation exchange-hydrophilic interaction liquid chromatography.