Direct connection gene sub-networks for the top 10% interconnected genes from each module of
the separate networks for female and male obtained by global literature analysis. (a)
Female; (b) male. Directly connected genes only are shown according to their location in
the cell (on the membrane, in the Golgi apparatus, nucleus, or cytoplasm or outside the cell). Node
shapes: oval and circle, protein; diamond, ligand; circle/oval on tripod platform, transcription
factor; ice cream cone, receptor; crescent, kinase or protein kinase; irregular polygon,
phosphatase. Color code: red, up-regulated genes; blue, down-regulated genes. Arrows with a plus
sign indicate positive regulation/activation; arrows with a minus sign indicate negative
regulation/inhibition; grey arrows represent regulation; lilac arrows represent expression; purple
arrows represent binding; green arrows represent promoter binding; yellow arrows represent protein
modification.