Table 2.
Several individual DNA methylation markers are associated with survival
| Statistics | KRT19 | FAS | CNR1 | HIST1H3C | ACSS3 | GNAS |
|---|---|---|---|---|---|---|
| HR-DOD versus LR-SURV (P-value OS) | 0.037 | 0.028 | 0.043 | 0.002 | 0.002 | 0.012 |
| HR-DOD versus LR-SURV (P-value EFS) | 0.039 | 0.049 | 0.039 | 0.039 | 0.079 | 0.039 |
| HR-DOD versus LR-SURV and HR-SURV (P-value OS) | 0.687 | 0.639 | 0.423 | 0.039 | 0.691 | 0.221 |
| HR-DOD versus LR-SURV and HR-SURV (P-value EFS) | 0.665 | 0.467 | 0.414 | 0.041 | 0.939 | 0.041 |
| HR-DOD versus LR-SURV and HR-SURV (P-value OS (stratum)) | Age < 12 months 0.035 | Stage 4 0.033 | MYCN = 0 0.033 | |||
| HR-DOD versus LR-SURV and HR-SURV (P-value EFS (stratum)) | Age < 12 months 0.014 | MYCN = 0 0.001 |
Log-rank test statistics (Mantel-Cox) are given (multiple testing correction by Benjamini-Hochberg) for comparison between the ultra-high risk group (HR-DOD) versus the low risk group (LR-SURV), and between the ultra-high risk group (HR-DOD) and all survivors (LR-SURV and HR-SURV). If a significant association (P < 0.05) was found in a particular stratum (associated with risk factors), this stratum is shown (multiple testing correction for the different comparisons by Benjamini-Hochberg). MYCN = 0: MYCN single copy ; EFS, event-free survival; OS, overall survival. P-values in bold indicate significant associations.