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. 2012 Oct 25;8(9):1267–1280. doi: 10.7150/ijbs.4828

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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Local events such as microbleeding in the joints are trigger factors for IL-6 amplifier activation, which causes arthritis in aged F759 mice that have an excess number of Th17 cells in the blood stream.