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Perturbation of T21 FL HSC/progenitor frequency. (A) Representative plots from normal FL (n = 13) and T21 FL (n = 8) CD34+ cells gated on CD34+CD38+CD19− cells for CMP, MEP, and GMP, and on CD34+CD38lo/− cells for HSC, MPP, and LMPP. (B) Mean + SEM HSC and progenitor frequencies in normal (n = 13; light bars) and T21 (n = 8) FL (dark bars) showing increased HSC and MEP frequency and reduced CBP and GMP. **P < 0.01; *P < 0.05.
