Fig. 3.

Effect of 18-d nerve blockade from SDLs on the onset of tactile hypersensitivity in the SNI model. (A) Thermal latency measurements in the ipsilateral limb. Mechanical withdrawal threshold measurements in the ipsilateral (B) and contralateral (C) hind limbs. Animals received SDLs on days 0, 5, and 12 (arrows in A). Shaded areas in B and C represent duration of nerve block (see A). Note that the time scale in A is different from those in panels B and C; dotted lines bridging A and B show the correspondence of the time frames. Data are means ± SD; *, ^†P < 0.05, n = 5 rats per group. (*, comparison between SNI- and SDL-treated SNI groups; ^†, comparison between SNI or SDL + SNI and respective preinjury levels at day 0.)