Table 3.
Incidence summary of anthrax-related microscopic observations with average severity scores in treated and untreated NHPs
| Tissue | Observation(s) | Treatment after anthrax challenge | Total no. of animals examineda | Lesion incidence (no. of animals) | Avg lesion severityb |
|---|---|---|---|---|---|
| Brain | Bacteria | Antibody | 3 | 3 | 3.0 |
| Untreated | 10 | 8 | 1.3 | ||
| Acute inflammation | Antibody | 3 | 3 | 3.7 | |
| Untreated | 10 | 1 | 0.4 | ||
| Hemorrhage | Antibody | 3 | 3 | 2.3 | |
| Untreated | 10 | 1 | 0.4 | ||
| Necrosis | Antibody | 3 | 3 | 1.0 | |
| Untreated | 10 | 1 | 0.1 | ||
| Liver | Bacteria | Antibody | 3 | 1 | 0.7 |
| Untreated | 10 | 8 | 1.5 | ||
| Acute inflammation | Antibody | 3 | 0 | 0.0 | |
| Untreated | 10 | 4 | 0.7 | ||
| Necrosis | Antibody | 3 | 0 | 0.0 | |
| Untreated | 10 | 6 | 1.2 | ||
| Sinusoidal leukocytosis | Antibody | 3 | 3 | 1.0 | |
| Untreated | 10 | 9 | 1.8 | ||
| Lymph node, mediastinal | Bacteria | Antibody | 3 | 1 | 0.3 |
| Untreated | 10 | 9 | 1.1 | ||
| Acute inflammation | Antibody | 3 | 1 | 0.7 | |
| Untreated | 10 | 5 | 0.6 | ||
| Depletion/necrosis, lymphocytes | Antibody | 3 | 2 | 1.3 | |
| Untreated | 10 | 10 | 2.5 | ||
| Edema | Antibody | 3 | 1 | 0.3 | |
| Untreated | 10 | 4 | 0.5 | ||
| Hemorrhage | Antibody | 3 | 0 | 0.0 | |
| Untreated | 10 | 8 | 1.6 |
a
Only animals that died on study were assessed for histopathology.
b
Lesions were graded on a scale of 1 to 4: 1, minimal (the least detectable lesion); 2, mild (easily discernible lesion); 3, moderate (change affecting a large area of represented tissues with potential to be relevant); and 4, marked (lesion that approached maximal).