Fig 5.
Antibacterial and anti-inflammatory effects of SMAMPs in a mouse model of acute infection with S. aureus. (A) C57BL/6 mice were infected intramuscularly with 1 × 105 S. aureus cells (ATCC 13709) in the right posterior thigh. The infected mice were injected intraperitoneally with 1 mg/kg SMAMP 02 or vehicle (HBSS containing 2% DMSO; control) at 1 h and 7 h after infection. The thighs were harvested 25 h after infection, and the bacterial burden was quantified by CFU enumeration. (B and C) Sera from the infected mice were assessed for TNF and IL-6 by ELISA. The results represent 4 to 5 mice per group in three independent experiments. The error bars indicate SEM.