Table 2.
Correlates of ELISpot responses among HESNa
| Characteristic | Median (IQR) or n (%) |
ORb | 95% CI | P value | |
|---|---|---|---|---|---|
| Responders (n = 34) | Non-responders (n = 297) | ||||
| Female (n) | 10 (29.4) | 106 (35.7) | 0.75 | 0.31–1.71 | 0.571 |
| Pregnancy during study (n) | 3 (8.8) | 42 (14.1) | 0.59 | 0.11–2.02 | 0.596 |
| Age (yr) | 32.5 (30, 46) | 32 (27, 38) | 1.24f | 1.03–1.51 | 0.026 |
| Less than primary education (n) | 12 (35.3) | 54 (18.2) | 2.45f | 1.04–5.54 | 0.024 |
| Yr living together | 6.5 (2.0, 13.0) | 4.0 (2.0, 9.0) | 5.88g | 1.80–19.16 | 0.003 |
| Lifetime partners (n) | 4.0 (3.0, 5.0) | 4.0 (2.0, 6.0) | 0.97 | 0.90–1.04 | 0.423 |
| Sex acts (n)c | 5.3 (2.0, 8.0) | 5.0 (2.5, 8.5) | 0.95 | 0.91–1.07 | 0.788 |
| Unprotected sex (n)c | 10 (29.4) | 82 (27.6) | 1.09 | 0.45–2.50 | 0.841 |
| History of STI (n) | 11 (33.3) | 105 (36.1) | 0.89 | 0.37–2.00 | 0.849 |
| Malaria (n)d | 2 (5.9) | 27 (9.1) | 0.63 | 0.07–2.70 | 0.752 |
| Genital sores (n)d | 0 (0.0) | 24 (8.1) | 0 | 0–1.30 | 0.152 |
| HSV-2 seropositive (n) | 17 (50.0) | 149 (50.2) | 0.99 | 0.46–2.16 | 0.999 |
| Circumcised (n)e | 22 (91.7) | 166 (86.9) | 1.66 | 0.37–15.37 | 0.746 |
| Partner's CD4 count (no. of cells/μl) | 476.0 (303.0, 617.0) | 400.5 (278.0, 617.0) | 1.09 | 0.94–1.26 | 0.238 |
| Partner's plasma viral load (no. of log10 RNA copies/ml) | 4.8 (3.9, 5.4) | 4.7 (4.0, 5.3) | 1.00 | 0.74–1.34 | 0.974 |
a
Analysis is restricted to samples with background of <50 SFU/106 PBMC. Odds ratios.
b
The OR for age and years living together is per 5 years. The OR for partner's CD4 count is per 100 cells/μl, and the OR for partner's plasma viral load is per log10 RNA copies/ml.
c
With study partner in the past month.
d
Self-reported in the past 3 months.
e
Males only.
f
P < 0.05.
g
P < 0.001.