Figure 2.
Average (mean ± SE) temporal normalized uptakes of untargeted fluorescence in the three tumor lines (red = human epidermoid carcinoma, A431; blue = human glioblastoma, U251; green = rat gliosarcoma, 9L-GFP) and in a reference tissue (purple = leg muscle) are presented in (a). The untargeted tracer K1/k2 ratio in each mouse for each tumor type (red = A431; blue = U251; green = 9L-GFP) is plotted against the untargeted K1/k2 ratio in a corresponding reference tissue in (b). The line of identity is indicated by the solid black line and the range for which the agreement between the tumor and reference tissue K1/k2 ratios would theoretically lead to an error in binding potential (BP) estimation of less than 50% is contained between the dashed black lines.