Table 1.

Receptor binding profile of 5-HT₄ agonists for GI disorders, at therapeutic concentrations

	Receptor binding profile at therapeutic concentrations
Drug	5-HT4	5-HT3	5-HT2	5-HT1	D2	hERG
Cisapride	+	+	+			+
Tegaserod	+	+	+	+
Renzapride	+	+
Clebopride	+	+			+
Mosapride	+	+
Prucalopride	+
Velusetrag	+
Naronapride	+

GI, gastrointestinal.

+ indicates affinity for this receptor (as either agonist or antagonist) that is likely to be clinically relevant at concentrations necessary for 5-HT₄ agonism (i.e. for therapeutic action). Information from De Maeyer et al.2008