Skip to main content
. 2012 Jan 10;22(12):2878–2893. doi: 10.1093/cercor/bhr365

Figure 7.

Figure 7.

Hippocampus formation in Emx1Cre;Gli3 conditional mouse mutants. (A,B) Gli3 is expressed at high levels in the dorsal telencephalon and in the LGE but at lower levels in the MGE of E10.5 control embryos (A), but Gli3 expression is lost from the dorsomedial telencephalon of conditional mutants (B). (C–H) Hippocampal marker gene expression in E18.5 control (C,E,G) and Emx1Cre;Gli3 conditional mutants (D,F,H). Expression of Nrp2 labels the whole hippocampal formation (C), while Scip1 is expressed in CA1 and in the neocortex (E). Prox1 expression is confined to the DG (G). In Emx1Cre;Gli3 conditional mutants, these hippocampal markers are expressed but their expression domains are severely reduced (D,F,H). Note that the Prox1+ cells do not form the characteristic blades of the DG (G).