Table 2.

World Health Organization 2010 Treatment Recommendations Based on Clinical Stage and CD4

WHO Stage	Age-Related Immunological Failure	Treatment Recommendation
Stage 1 or 2	No	Continue current regimen
		Intensify follow-up if CD4 falls to near age-related threshold
	Yes	Consider switch only if ≥2 CD4 measurements are below age-related threshold
Stage 3	No	Intensify follow-up if CD4 falls to near age-related threshold
	Yes	Switch regimen, especially if good initial immune response to ART
Stage 4	No	Switching may not be necessary
	Yes	Switch regimen, especially if good initial immune response to ART

Abbreviations: ART, antiretroviral therapy; WHO, World Health Organization.