Fig. 2.

Silencing of TBE transposases leads to accumulation of aberrantly processed DNA. MDS segments (white boxes) and IESs (hatched boxes) are shown schematically and not to scale. Shown are the sequences of PCR products for TEBPβ between segments 2 and 7 in the progeny of triply silenced cells treated 12 to 15 hours after mixing; shown are all 32 examples of aberrantly rearranged chromosomes found among 37 sequenced clones [redundancy is indicated by the number after an x (table S2)]. Open triangles indicate locations of cryptic junctions between neighboring (pointing up) and nonneighboring (pointing down) segments on the basis of precursor micronuclear order. MIC, nonrearranged micronuclear gene sequences; MAC, expected rearranged macronuclear gene sequences.