TABLE 1.

Mean SNR and Percent Decrease in SNR in the Cortex and Basal Ganglion Regions in Different Dosage Groups

	SNR in the Cortex ± σ			SNR in the Basal Ganglia ± σ
USPIO	Pre-USPIO	Post-USPIO	% Decrease	Pre-USPIO	Post-USPIO	% Decrease
1 mg Fe/kg	14.5 ± 1.0	13.9 ± 1.6	3.80	15.1 ± 0.9	14.3 ± 1.2	5.44
2 mg Fe/kg	18.7 ± 0.9	17.5 ± 0.5	6.53	17.2 ± 1.4	16.0 ± 0.9	6.59
3 mg Fe/kg	14.5 ± 2.9	11.9 ± 2.3	17.83*	14.1 ± 1.2	10.9 ± 0.6	22.42*

^*Mean SNR and percent decrease in the 3-mg Fe/kg group are significantly different from either 1 or 2 mg Fe/kg in both cortical and basal ganglion regions (P < 0.0167, Student t test with Bonferroni correction).