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. 2012 Jul 5;4(9):882–895. doi: 10.1002/emmm.201201228

Figure 5. Statins induce miR-33 and reduce the mRNA expression of specific hepatic canalicular transporters.

Figure 5

  • A, B. C57BL/6 mice (n = 5) were gavaged daily with statins, and kept on chow diet. Samples were collected after 7 days, following an overnight fasting.
  • C. HuH7 cells were cultured in quadruplicate for 48 h in DMEM supplemented with 2% lipoprotein-deficient serum in the presence or absence of simvastatin. Relative expression of specific genes shown as mean ± SD; *p < 0.05; **p < 0.01.