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In vitro kinetic parameters of M. tuberculosis InhA and its inhibition by pyridomycin
| Wild-type InhA | InhA (S94A) | InhA (D148G) | |
|---|---|---|---|
| NADH Km (µM) | 13.5 ± 2.3 | 83.5 ± 9.5 | 190 ± 16 |
| NADH Vmax (µmol/min/mg) | 0.52 ± 0.03 | 0.50 ± 0.02 | 0.54 ± 0.3 |
| Pyridomycin Ki (µM) | 6.5 ± 1.2 | 5.0 ± 0.4 | No inhibition at 18.6 µM |
