Skip to main content
. 2012 Oct 2;4(10):1072–1086. doi: 10.1002/emmm.201201374

Figure 1. IL-13 administration alters plaque morphology of established atherosclerotic lesions.

Figure 1

  1. LDLR−/− mice were fed an atherogenic diet for 16 weeks and received biweekly intraperitoneal injections with PBS (n = 11) or IL-13 (n = 13) during the last 5 weeks. Equal extent of atherosclerotic lesion size in cross-sections of the aortic origin in injected LDLR−/− mice. Values represent µm2/section throughout the entire aortic origin (300 µm). Original magnification 50×.
  2. Increased collagen content in lesions of LDLR−/− mice injected with IL-13. Sections were stained with Sirius Red for the presence of collagen, and values represent the percentages of Sirius Red+ area/total lesion area. *p = 0.035. Original magnification 100×.
  3. Decreased macrophage content in lesions of LDLR−/− mice injected with IL-13. Sections were stained with the macrophage-specific anti-mac-3 antibody and values represent the numbers of mac-3+ cells/mm2 of total lesion area. ***p = 0.0007. Original magnification 100×. All data are mean ± SEM values of all mice of each group. Images show representative examples of the respective stainings.