Table 1.
Resistance Mutations in HIV-1 Reverse Transcriptase Associated With Failure Among Participants Treated With Efavirenz or Nevirapine and Stavudine-Lamivudine.
| Domain | Mutation | Mutations With EFV, % (No.; n = 41) |
Mutations With NVP, % (No.; n = 22) |
||||
|---|---|---|---|---|---|---|---|
| Before Therapy | At Failure | P | Before Therapy | At Failure | P | ||
| Polymerase | A62V | 0.0 (0) | 7.3 (3) | .25 | 0.0 (0) | 0.0 (0) | … |
| K65R | 0.0 (0) | 4.9 (2) | .50 | 0.0 (0) | 0.0 (0) | … | |
| D67N | 0.0 (0) | 2.4 (1) | 1.0 | 0.0 (0) | 0.0 (0) | … | |
| K70R | 0.0 (0) | 2.4 (1) | 1.0 | 0.0 (0) | 0.0 (0) | … | |
| V75I | 0.0 (0) | 2.4 (1) | 1.0 | 0.0 (0) | 4.5 (1) | 1.0 | |
| V90I | 0.0 (0) | 4.9 (2) | .50 | 0.0 (0) | 0.0 (0) | … | |
| A98G | 0.0 (0) | 0.0 (0) | … | 0.0 (0) | 4.5 (1) | 1.0 | |
| K101E | 2.4 (1) | 12.0 (5) | .22 | 0.0 (0) | 4.5 (1) | 1.0 | |
| K103N | 4.9 (2) | 54.0 (22) | <.0001 | 14.0 (3) | 32.0 (7) | .13 | |
| V106A/I | 0.0 (0) | 2.4 (1) | 1.0 | 0.0 (0) | 18.0 (4) | .13 | |
| V106M | 0.0 (0) | 22.0 (9) | .004 | 4.5 (1) | 9.0 (2) | 1.0 | |
| V108I | 0.0 (0) | 2.4 (1) | 1.0 | 0.0 (0) | 9.0 (2) | .50 | |
| V179D | 2.4 (1) | 4.9 (2) | 1.0 | 0.0 (0) | 0.0 (0) | … | |
| Y181C | 2.4 (1) | 0.0 (0) | 1.0 | 0.0 (0) | 41.0 (9) | .004 | |
| M184V | 0.0 (0) | 71.0 (29) | <.0001 | 0.0 (0) | 73.0 (16) | <.0001 | |
| Y188C/H | 0.0 (0) | 7.3 (3) | .25 | 0.0 (0) | 0.0 (0) | … | |
| G190A/S | 4.9 (2) | 12.0 (5) | .37 | 0.0 (0) | 9.0 (2) | .50 | |
| K219E | 0.0 (0) | 2.4 (1) | 1.0 | 0.0 (0) | 0.0 (0) | … | |
| P225H | 0.0 (0) | 12.0 (5) | .06 | 0.0 (0) | 0.0 (0) | … | |
| M230L | 0.0 (0) | 4.9 (2) | .50 | 0.0 (0) | 4.5 (1) | 1.0 | |
| Connection | D324E | 10.0 (4) | 17.0 (7) | .25 | 0.0 (0) | 0.0 (0) | … |
| N348I | 0.0 (0) | 12.0 (5) | .06 | 0.0 (0) | 45.0 (10) | .002 | |
| V365I | 4.9 (2) | 10.0 (4) | .50 | 14.0 (3) | 18.0 (4) | 1.0 | |
| T369I | 0.0 (0) | 7.3 (3) | .25 | 0.0 (0) | 0.0 (0) | … | |
| A371V | 0.0 (0) | 4.9 (2) | .50 | 0.0 (0) | 0.0 (0) | … | |
| M377R | 0.0 (0) | 0.0 (0) | … | 0.0 (0) | 9.0 (2) | .50 | |
| D404N | 0.0 (0) | 7.3 (3) | .25 | 0.0 (0) | 9.0 (2) | .50 | |
| RNase H | I452L | 32.0 (13) | 37.0 (15) | .50 | 45.0 (10) | 27.0 (6) | .13 |
| V467I | 24.0 (10) | 27.0 (11) | 1.0 | 32.0 (7) | 41.0 (9) | .50 | |
| L517I | 12.0 (5) | 22.0 (9) | .13 | 9.0 (2) | 18.0 (4) | .50 | |
Abbreviations: EFV, efavirenz; NVP, nevirapine; RNase H, ribonuclease H.