Table 5.

Laboratory Evaluations

	Baseline	Days 1–7	Days 8–14	Days 15–21	Days 22–28
Serum creatinine (No.)	181	173	127	85	53
Median (range), mg/dL	0.5 (0.1–1.9)	0.4 (0.0–3.1)	0.4 (0.0–2.7)	0.3 (0.0–2.9)	0.3 (0.0–2.0)
AST (No.)	60	78	68	55	32
Median (range), U/L	37 (12–3358)	33 (9–419)	33 (11–308)	40 (15–567)	50 (19–788)
ALT (No.)	60	80	69	55	30
Median (range), U/L	25 (4–956)	18 (5–140)	16 (4–131)	20 (5–605)	27 (8–168)
Alkaline phosphatase (No.)	64	86	65	52	28
Median (range), U/L	255 (72–1368)	244 (35–967)	321 (104–1103)	412 (101–1600)	508 (123–1145)
Direct bilirubin (No.)	70	71	52	34	14
Median (range), mg/dL	0.6 (0.0–10.8)	0.8 (0.0–10.3)	1.5 (0.0–10.7)	1.7 (0.1–8.5)	3.7 (0.2–6.0)

Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase.