Table 4.
Association of Type of Exogenous Menopausal Hormone Use with Risk of Glioma Among 134,514 Women in the NIH-AARP Diet and Health Study
| Cases (N = 106) | Person-years | HRa (95% CI) | |
|---|---|---|---|
| Any menopausal hormone | |||
| Never | 38 | 377,352 | 1.00 (reference) |
| Ever | 61 | 582,311 | 0.99 (0.63, 1.56) |
| Estrogen pills | |||
| Never | 39 | 386,862 | 1.00 (reference) |
| Ever | 57 | 542,592 | 0.97 (0.61, 1.54) |
| Duration of estrogen pill use | |||
| Never | 38 | 383,790 | 1.00 (reference) |
| 1–9 yrs | 34 | 293,431 | 1.31 (0.79, 2.17) |
| ≥10 yrs | 23 | 241,723 | 0.69 (0.38, 1.28) |
| Progestin pills | |||
| Never | 65 | 650,772 | 1.00 (reference) |
| Ever | 30 | 277,596 | 1.24 (0.75, 2.05) |
| Duration of progestin pill use | |||
| Never | 61 | 641,280 | 1.00 (reference) |
| 1–9 yrs | 22 | 205,138 | 1.39 (0.80, 2.42) |
| ≥10 yrs | 8 | 64,770 | 1.02 (0.40, 2.59) |
Abbreviations: HR, hazard ratio; CI, confidence interval.
a
Each variable in the table is adjusted for: age at entry (continuous), race (white/non-white), age at menarche (<13, 13–14, ≥15), parous/nulliparous, age at menopause (<45, 45–49, ≥50), history of hysterectomy (yes/no), and smoking status (never, former, current smoker).