Table 4.

Associations Between Acute Air Pollution Exposure and iNOS^a Promoter Methylation by Psychological Factor in the Normative Aging Study, 1999–2009

4-Hour Exposure Period	% Change in 5-Methylcytosine		Pinteraction	% Change in 5-Methylcytosine		Pinteraction
	Per 1 μg/m3 Black Carbonb	95% Confidence Interval		Per 10 μg/m3 PMc2.5	95% Confidence Interval
High pessimism	−1.005	−1.742, −0.268	0.867	−0.788	−1.532, −0.043	0.925
Low pessimism	−0.924	−1.580, −0.269		−0.835	−1.593, −0.077
High optimism	−0.480	−1.134, 0.173	0.048	−0.835	−1.593, −0.077	0.050
Low optimism	−1.432	−2.168, −0.696		−1.267	−2.044, −0.490
High depression	−0.833	−2.252, 0.586	0.878	−1.057	−2.335, 0.222	0.558
Low depression	−0.950	−1.492, −0.407		−0.650	−1.254, −0.046
High anxiety	−2.0976	−3.419, −0.777	0.053	−1.657	−2.893, −0.422	0.101
Low anxiety	−0.6564	−1.203, −0.110		−0.548	−1.153, 0.057

Abbreviation: PM_2.5, particulate matter less than 2.5 µm in diameter.

^a iNOS, inducible nitric oxide synthase gene.

^b Models were adjusted for baseline age, season, and time trend, apparent temperature, percent lymphocytes, percent neutrophils, and black carbon exposure in the 2 weeks prior to examination.

^c Models were adjusted for baseline age, season, and time trend, apparent temperature, percent lymphocytes, and percent neutrophils.