Fig. 8.

Lithographically-structured and self-assembled containers. (a) Schematic representation of a spherical particle and lithographically-fabricated microdevice interface with intestinal epithelial cell surface. This illustration displays the advantages of a microfabricated drug delivery particle over traditional spherical particles: asymmetric release of drug, multi-site targeting for flow stability, and drug reservoir protection can be engineered into the design of the microdevice. (Reprinted from ref. 100 with permission from The Royal Society of Chemistry). (b) Light micrograph of detached SU-8 microdevices without hydrogel. (Reprinted from ref. 100 with permission from The Royal Society of Chemistry). (c) Fluorescence images of cubic (side length 2 μm), Doxorubicin-loaded Trojan horse particles produced using the PRINT technique. (Reprinted with permission from ref. 106. Copyright (2008) by The American Chemical Society). (d) Manipulation of shape using PRINT: 3 μm arrow PEG particles. (Reprinted with permission from ref. 104. Copyright (2005) by The American Chemical Society). (e) Video snapshots featuring the hierarchical self-assembly of a 500 μm dodecahedron. (Reprinted with permission from ref. 111. Copyright (2009) by IOP Publishing Ltd.). (f) An SEM image of a folded 3D dodecahedron container featuring anisotropic surface patterning (i.e., different specific desired patterns on each panel). (Reprinted with permission from ref. 111. Copyright (2009) by IOP Publishing Ltd.).