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. 2012 Oct 3;5:17. doi: 10.1186/1756-0381-5-17

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Copyright ©2012 Satoh; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MicroRNA targetome suggests aberrant upregulation of cell cycle regulators in AD brains. The targets for the set of miRNAs downregulated in AD brains were identified by searching them on the miRTarBase [18]. The expression of targets in the human brain was verified by searching them on UniGene. Overall, 852 theoretically upregulated target genes for the set of miRNAs downregulated in AD brains were imported into the Core Analysis tool of IPA. The canonical pathway defined by “Cyclins and Cell Cycle Regulation” showing a significant relationship with the targetome (p = 2.18E-19) is shown. The red nodes represent cell cycle regulators theoretically upregulated in AD brains.