Figure 1.

Simulated and observed Extracellular matrix gene family mutations in ovarian cancer. (a) Histogram showing the ratio of mutations in cell adhesion genes in the observed dataset (in red) and the ratio of mutations in cell adhesion genes to total mutations in simulated mutagenesis data (in blue). (b) Mutation rates were normalized to gene numbers in the family and compared to the baseline of all mutations in all genes. Collagens and Laminins had higher than expected mutation rates while the large gene family of Integrins had lower mutation rates.