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Effects of FoxM1 depletion on cell growth.A, FoxM1 mRNA levels were down-regulated by FoxM1 siRNA. B, FoxM1 protein levels were down-regulated by siRNA. C, Inhibition of cancer cell proliferation by FoxM1 siRNA tested by MTT assay. D, Inhibition of cancer cell colony formation capacity by FoxM1 siRNA. Experiments were repeated at least three times, and representative data are presented; bars, SD.*, P < 0.05; **, P < 0.01, relative to control.
