Table 2.
Relative and absolute risks of subsequent tobacco-related primary cancer according to type of first tobacco-related primary cancer and sex (Bavaria; 2002–2008)
| Men | Women | ||||||
|---|---|---|---|---|---|---|---|
|
First tobacco-related primary cancer |
Subsequent tobacco-related primary cancer |
O |
SIR (95% CI) |
EAR |
O |
SIR (95% CI) |
EAR |
| mouth, pharynx |
oesophagus |
86 |
19.63 (15.71-24.25) |
45.6 |
15 |
48.06 (26.9-79.27) |
24.7 |
| |
stomach |
24 |
2.87 (1.84-4.27) |
8.7 |
2 |
0.93 (0.11-3.35) |
−0.3 |
| |
colon, rectum |
54 |
1.65 (1.24-2.15) |
11.9 |
12 |
1.42 (0.74-2.49) |
6.0 |
| |
pancreas |
9 |
1.36 (0.62-2.58) |
1.3 |
2 |
0.92 (0.11-3.31) |
−0.3 |
| |
larynx |
43 |
14.10 (10.21-18.99) |
22.3 |
7 |
69.05 (27.76-142.26) |
11.6 |
| |
bronchus, lung |
201 |
7.90 (6.85-9.07) |
98.1 |
42 |
12.36 (8.91-16.71) |
65.0 |
| |
kidney |
17 |
2.11 (1.23-3.38) |
5.0 |
2 |
1.27 (0.15-4.60) |
0.7 |
| |
urinary tract |
3 |
2.82 (0.58-8.24) |
1.1 |
- |
- |
- |
| |
urinary bladder |
18 |
1.28 (0.76-2.02) |
2.2 |
2 |
1.18 (0.14-4.28) |
0.5 |
| |
leukemia |
14 |
3.03 (1.66-5.09) |
5.2 |
2 |
1.59 (0.19-5.75) |
1.25 |
| oesophagus |
mouth, pharynx |
36 |
14.18 (9.93-19.64) |
70.3 |
5 |
34.92 (11.34-81.48) |
49.4 |
| |
stomach |
5 |
1.64 (0.53-3.82) |
4.1 |
1 |
2.41 (0.06-13.42) |
6.0 |
| |
colon, rectum |
23 |
1.99 (1.26-2.98) |
24.0 |
6 |
3.70 (1.36-8.05) |
44.5 |
| |
pancreas |
5 |
2.15 (0.70-5.01) |
5.6 |
2 |
4.71 (0.57-17.00) |
16.0 |
| |
larynx |
7 |
7.44 (2.99-15.33) |
12.7 |
- |
- |
- |
| |
bronchus, lung |
23 |
2.62 (1.66-3.92) |
29.9 |
6 |
9.42 (3.46-20.50) |
54.5 |
| |
kidney |
8 |
2.97 (1.28-5.86) |
11.2 |
2 |
6.54 (0.79-23.62) |
17.2 |
| |
urinary tract |
1 |
2.53 (0.06-14.12) |
1.3 |
- |
- |
- |
| |
urinary bladder |
12 |
2.34 (1.21-4.09) |
14.4 |
1 |
3.07 (0.08-17.13) |
6.9 |
| |
leukemia |
6 |
3.65 (1.34-7.94) |
9.2 |
- |
- |
- |
| stomach |
mouth, pharynx |
6 |
0.97 (0.36-2.12) |
−0.1 |
1 |
0.70 (0.02-3.91) |
−0.4 |
| |
oesophagus |
8 |
2.07 (0.90-4.09) |
3.3 |
1 |
1.56 (0.04-8.71) |
0.4 |
| |
colon, rectum |
68 |
1.68 (1.30-2.13) |
21.8 |
40 |
1.86 (1.33-2.54) |
18.9 |
| |
pancreas |
17 |
2.09 (1.22-3.34) |
7.0 |
13 |
2.24 (1.19-3.83) |
7.3 |
| |
larynx |
3 |
1.18 (0.24-3.43) |
0.4 |
- |
- |
- |
| |
bronchus, lung |
33 |
1.15 (0.79-1.62) |
3.5 |
9 |
1.34 (0.61-2.54) |
2.3 |
| |
kidney |
19 |
2.26 (1.36-3.53) |
8.4 |
6 |
1.66 (0.61-3.62) |
2.4 |
| |
urinary tract |
1 |
0.65 (0.02-3.64) |
−0.4 |
- |
- |
- |
| |
urinary bladder |
17 |
0.87 (0.51-1.39) |
−2.0 |
3 |
0.69 (0.14-2.01) |
−1.4 |
| |
leukemia |
11 |
1.80 (0.90-3.22) |
3.9 |
6 |
1.88 (0.69-4.09) |
2.9 |
| colon, rectum |
mouth, pharynx |
56 |
1.48 (1.12-1.92) |
2.5 |
13 |
1.50 (0.80-2.56) |
0.7 |
| |
oesophagus |
31 |
1.33 (0.91-1.89) |
1.1 |
8 |
2.07 (0.89-4.08) |
0.7 |
| |
stomach |
73 |
1.11 (0.87-1.40) |
1.0 |
45 |
1.31 (0.96-1.75) |
1.8 |
| |
pancreas |
43 |
0.92 (0.66-1.23) |
−0.5 |
44 |
1.30 (0.94-1.74) |
1.7 |
| |
larynx |
15 |
0.97 (0.54-1.60) |
−0.1 |
- |
- |
- |
| |
bronchus, lung |
210 |
1.26 (1.09-1.44) |
5.8 |
60 |
1.47 (1.12-1.89) |
3.3 |
| |
kidney |
85 |
1.71 (1.37-2.12) |
4.8 |
36 |
1.67 (1.17-2.31) |
2.5 |
| |
urinary tract |
12 |
1.40 (0.72-2.44) |
0.5 |
7 |
1.86 (0.75-3.84) |
0.6 |
| |
urinary bladder |
148 |
1.34 (1.13-1.58) |
5.1 |
38 |
1.49 (1.06-2.05) |
2.1 |
| |
leukemia |
59 |
1.71 (1.3-2.21) |
3.3 |
32 |
1.73 (1.18-2.44) |
2.3 |
| pancreas |
mouth, pharynx |
1 |
0.47 (0.01-2.59) |
−2.7 |
1 |
1.77 (0.04-9.87) |
1.1 |
| |
oesophagus |
1 |
0.80 (0.02-4.48) |
−0.6 |
- |
- |
- |
| |
stomach |
9 |
2.91 (1.33-5.52) |
14.1 |
7 |
3.60 (1.45-7.42) |
12.7 |
| |
colon, rectum |
16 |
1.41 (0.81-2.29) |
11.1 |
12 |
1.63 (0.84-2.84) |
11.6 |
| |
larynx |
3 |
3.57 (0.74-10.43) |
5.2 |
- |
- |
- |
| |
bronchus, lung |
10 |
1.18 (0.57-2.18) |
3.7 |
3 |
1.12 (0.23-3.26) |
0.8 |
| |
kidney |
4 |
1.58 (0.43-4.04) |
3.5 |
4 |
2.88 (0.79-7.39) |
6.6 |
| |
urinary bladder |
7 |
1.36 (0.55-2.81) |
4.5 |
- |
- |
- |
| |
leukemia |
1 |
0.61 (0.02-3.40) |
−1.5 |
2 |
1.82 (0.22-6.58) |
2.26 |
| larynx |
mouth, pharynx |
33 |
8.83 (6.08-12.41) |
41.9 |
3 |
26.52 (5.47-77.51) |
34.8 |
| |
oesophagus |
18 |
8.92 (5.28-14.09) |
22.9 |
1 |
23.53 (0.60-131.09) |
11.6 |
| |
stomach |
5 |
1.10 (0.36-2.57) |
0.7 |
1 |
3.95 (0.10-22.03) |
9.0 |
| |
colon, rectum |
18 |
1.05 (0.63-1.67) |
1.3 |
- |
- |
- |
| |
pancreas |
9 |
2.61 (1.19-4.95) |
7.9 |
1 |
3.74 (0.09-20.82) |
8.8 |
| |
bronchus, lung |
69 |
5.37 (4.18-6.80) |
80.4 |
9 |
18.83 (8.61-35.75) |
102.9 |
| |
kidney |
6 |
1.53 (0.56-3.32) |
3.0 |
- |
- |
- |
| |
urinary tract |
1 |
1.71 (0.04-9.53) |
0.6 |
- |
- |
- |
| |
urinary bladder |
10 |
1.31 (0.63-2.41) |
3.4 |
1 |
4.79 (0.12-26.68) |
9.6 |
| |
leukemia |
2 |
0.82 (0.10-2.97) |
−0.6 |
- |
- |
- |
| bronchus, lung |
mouth, pharynx |
42 |
3.48 (2.51-4.71) |
13.1 |
10 |
6.46 (3.10-11.88) |
7.5 |
| |
oesophagus |
20 |
2.83 (1.73-4.37) |
5.6 |
3 |
4.84 (1.00-14.14) |
2.1 |
| |
stomach |
28 |
1.60 (1.06-2.31) |
4.6 |
12 |
2.88 (1.49-5.03) |
6.9 |
| |
colon, rectum |
71 |
1.10 (0.86-1.39) |
2.8 |
17 |
1.02 (0.59-1.63) |
0.3 |
| |
pancreas |
19 |
1.47 (0.89-2.30) |
2.7 |
10 |
2.31 (1.11-4.24) |
5.0 |
| |
larynx |
37 |
7.78 (5.48-10.72) |
14.1 |
1 |
4.94 (0.12-27.50) |
0.7 |
| |
kidney |
32 |
2.21 (1.51-3.12) |
7.6 |
13 |
3.94 (2.10-6.74) |
8.6 |
| |
urinary tract |
6 |
2.62 (0.96-5.71) |
1.6 |
3 |
5.93 (1.22-17.33) |
2.2 |
| |
urinary bladder |
63 |
2.15 (1.65-2.75) |
14.7 |
9 |
2.69 (1.23-5.11) |
5.0 |
| |
leukemia |
16 |
1.72 (0.98-2.80) |
2.9 |
3 |
1.21 (0.25-3.53) |
0.5 |
| kidney |
mouth, pharynx |
10 |
1.11 (0.53-2.03) |
0.5 |
1 |
0.62 (0.02-3.44) |
−0.5 |
| |
oesophagus |
4 |
0.76 (0.21-1.95) |
−0.7 |
- |
- |
- |
| |
stomach |
15 |
1.14 (0.64-1.89) |
1.1 |
5 |
0.90 (0.29-2.09) |
−0.5 |
| |
colon, rectum |
51 |
1.06 (0.79-1.39) |
1.5 |
25 |
1.17 (0.76-1.73) |
3.2 |
| |
pancreas |
9 |
0.93 (0.42-1.76) |
−0.4 |
5 |
0.87 (0.28-2.02) |
−0.7 |
| |
larynx |
3 |
0.86 (0.18-2.50) |
−0.3 |
1 |
5.08 (0.13-28.28) |
0.7 |
| |
bronchus, lung |
54 |
1.51 (1.13-1.97) |
10.1 |
16 |
2.06 (1.18-3.34) |
7.1 |
| |
urinary tract |
3 |
1.75 (0.36-5.12) |
0.7 |
3 |
4.47 (0.92-13.07) |
2.0 |
| |
urinary bladder |
51 |
2.31 (1.72-3.03) |
16.1 |
10 |
2.29 (1.10-4.21) |
4.9 |
| |
leukemia |
12 |
1.72 (0.89-3.00) |
2.8 |
2 |
0.63 (0.08-2.28) |
−1.0 |
| urinary tract |
oesophagus |
1 |
1.64 (0.04-9.15) |
2.0 |
- |
- |
- |
| |
stomach |
2 |
1.05 (0.13-3.80) |
0.5 |
- |
- |
- |
| |
colon, rectum |
12 |
1.84 (0.95-3.21) |
28.5 |
4 |
1.21 (0.33-3.10) |
4.9 |
| |
pancreas |
3 |
2.28 (0.47-6.66) |
8.8 |
3 |
3.35 (0.69-9.78) |
14.7 |
| |
bronchus, lung |
9 |
1.96 (0.89-3.72) |
22.9 |
4 |
3.82 (1.04-9.77) |
20.7 |
| |
kidney |
4 |
2.97 (0.81-7.60) |
13.8 |
- |
- |
- |
| |
urinary bladder |
5 |
1.58 (0.51-3.68) |
9.5 |
12 |
17.84 (9.22-31.15) |
79.3 |
| |
leukemia |
2 |
2.03 (0.25-7.32) |
5.3 |
- |
- |
- |
| urinary bladder |
mouth, pharynx |
25 |
1.41 (0.91-2.08) |
2.0 |
3 |
1.63 (0.34-4.77) |
1.0 |
| |
oesophagus |
12 |
1.05 (0.54-1.83) |
0.2 |
3 |
3.60 (0.74-10.53) |
1.8 |
| |
stomach |
41 |
1.13 (0.81-1.53) |
1.3 |
16 |
2.10 (1.20-3.40) |
6.8 |
| |
colon, rectum |
144 |
1.16 (0.98-1.36) |
5.5 |
26 |
0.95 (0.62-1.39) |
−1.2 |
| |
pancreas |
31 |
1.24 (0.84-1.75) |
1.7 |
6 |
0.80 (0.29-1.74) |
−1.2 |
| |
larynx |
4 |
0.53 (0.15-1.36) |
−1.0 |
- |
- |
- |
| |
bronchus, lung |
187 |
2.16 (1.86-2.49) |
27.9 |
25 |
2.87 (1.85-4.23) |
13.3 |
| |
kidney |
77 |
3.04 (2.40-3.80) |
14.4 |
12 |
2.56 (1.32-4.48) |
6.0 |
| |
urinary tract |
7 |
1.47 (0.59-3.03) |
0.6 |
6 |
7.26 (2.66-15.79) |
4.2 |
| |
leukemia |
30 |
1.59 (1.07-2.27) |
3.1 |
8 |
1.96 (0.85-3.87) |
3.2 |
| leukemia |
mouth, pharynx |
3 |
0.73 (0.15-2.13) |
−1.2 |
2 |
2.42 (0.29-8.73) |
1.8 |
| |
oesophagus |
5 |
2.10 (0.68-4.89) |
2.9 |
- |
- |
- |
| |
stomach |
9 |
1.43 (0.66-2.72) |
3.0 |
4 |
1.50 (0.41-3.84) |
2.0 |
| |
colon, rectum |
27 |
1.19 (0.79-1.74) |
4.8 |
14 |
1.37 (0.75-2.30) |
5.8 |
| |
pancreas |
6 |
1.32 (0.48-2.87) |
1.6 |
4 |
1.48 (0.40-3.78) |
2.0 |
| |
larynx |
1 |
0.63 (0.02-3.48) |
−0.7 |
- |
- |
- |
| |
bronchus, lung |
27 |
1.63 (1.08-2.38) |
11.5 |
7 |
1.83 (0.74-3.77) |
4.8 |
| |
kidney |
7 |
1.40 (0.56-2.89) |
2.2 |
- |
- |
- |
| |
urinary tract |
3 |
3.68 (0.76-10.76) |
2.4 |
- |
- |
- |
| urinary bladder | 11 | 1.05 (0.52-1.87) | 0.5 | 4 | 1.94 (0.53-4.97) | 3.0 | |
O, number of observed cases; SIR, standardized incidence ratio; 95% CI, 95% confidence interval; EAR, excess absolute risk per 10,000; bold type, SIR significantly different from one.