Table 2. fMRI group analysis of the tapping test performed by PD patients (N = 12) before and after implantation of the electrodes bilaterally to the STN in absence of DBS.

	UPDRS-III cov.							oedema cov.
	x	y	z	k	T†	p †		T#	p #
a) before vs. after-implantation (BOLD decrease):
precentral g. (SM1)
right	21	−28	58	113	4.69	10−5	**	4.51	10−5	***
left	−21	−31	52	410‡	4.63	10−5	***	4.62	10−5	***
middle cingulate and SMA	3	−25	40	410‡	4.40	10−4	***	3.56	10−4	***
rollandic operculum
right (OP4)	66	−7	10	44	4.30	10−4	*	5.47	10−6	***
left (OP1)	−60	−16	10	11	4.21	10−4		4.26	10−4	***
thalamus
right (anterior/dorsal)	9	−3	6	410‡	4.24	10−4	***	4.72	10−5	***
right (lateral)	15	−13	4	410‡	4.49	10−4	***	5.33	10−5	***
left (anterior/dorsal)	−12	−7	1	326	3.67	10−3	***	4.70	10−5	***
left (lateral)	−13#	−11#	1#		3.57	10−3		4.13	10−4	***
putamen and globus pallidus
right	18#	6#	−6#		2.81	10−2		4.46	10−4	***
left	−27	−4	10	326	4.11	10−4	*	3.66	10−4	***
insula
right	48	8	−8	81	4.32	10−4	**	5.19	10−5	***
left	−42	5	−5	410‡	4.33	10−4	***	3.66	10−4	***
b) rigidity score (BOLD decrease):
putamen and globus pallidus
right	30	−1	11	96	4.33	10−4	**
left	−30	−1	−8	223	4.88	10−6	***
c) akinesia score:
none
d) tremor score:
none
e) axial score (BOLD decrease):
putamen and globus pallidus
right	30	−7	−2	40	3.94	10−4
left	−30	−4	−2	112	4.82	10−5	**

a) Contrast showing decrease of the BOLD signal after implantation (OFF state) as compared to situation before implantation (OFF state) with the UPDRS-III or the oedema score as covariates; x, y, z – local maxima of clusters in MNI coordinates derived from the contrast before vs. after implantation with the UPDRS-III covariate; k – size of the cluster in voxels;

^‡- regions belonging to the same cluster; T – T-score; p – uncorrected level of significance;

^*(p<0.05),

^**(p<0.01),

^***(p<0.001) – significance with FWE correction at cluster-level;

^†– values derived from the contrast before vs. after implantation with the UPDRS-III covariate;

^#– values derived from the contrast before vs. after implantation with the oedema covariate.

b), c), d), e) – Impact of the UPDRS-III sub-scores on size of the BOLD response expressed as inverse effects of rigidity and axial covariates.