Figure 8. (A,B) The effect of NS 398 (10−6 M) and (D,E) furegrelate (FU, 10−3 M) on the concentration-response curves for phenylephrine in aortic rings in control (CT) conditions or HgCl2.
Results (mean±SEM) are expressed as a percentage of the response to 75 mmol/l KCl. *P<0.05 by ANOVA. Number of animals used in parentheses. (C, F) Differences in the area under the concentration-response curve (dAUC) in aortic rings cultured in the presence of NS 398 (10−6 M) and furegrelate (FU, 10−3 M) under control (CT) conditions and after acute incubation with mercury HgCl2. *P<0.05 by Student’s t-test. Densitometric analysis of the western blot for cycloxxigenase-2 (COX-2) protein expression in aortic rings in control (CT) conditions or HgCl2. *P<0.05 by Student’s t-test. Number of animals used in parentheses. Representative blots are also shown.