Figure 8. Normal proliferative responses in T-cells of Ptprz-deficient mice.

T-cell preparations taken from the axillary and inguinal lymph nodes of mice at 10, 28, or 35 days after MOG immunization (imm.), or non-immunized control (non) mice were cultivated in the presence of the MOG peptide (top), anti-CD3/CD28 antibodies (middle), or vehicle (bottom). BrdU incorporation was measured as an index of cell proliferation, and is expressed as the relative change (fold-increase) compared with the vehicle-treated sample of the non-immunized wild-type control. Data are the mean ± SEM (n = 6 for each group). No significant differences were detected between the two genotypes. a.u., arbitrary unit.