. 2012 Nov 7;7(11):e48790. doi: 10.1371/journal.pone.0048790

Table 4. Energy expenditure and respiratory quotient in ShcKO and wild-type (WT) mice housed at 12°C.¹ .

	P66 Shc(−/−)			WT			P Value
	3 mo	15 mo	27 mo	3 mo	15 mo	27 mo	Geno	Age	Geno*Age
Fasted
RQ	0.824±0.015^a	0.776±0.0054^b	0.785±0.007^b	0.0813±0.013^a	0.769±0.0032^b	0.782±0.0045^b	0.420	0.0002	0.922
RQ_MEI ^α	0.826±0.0107^a	0.774±0.0124^b	0.787±0.0101^b	0.811±0.0082^a	0.764±0.0135^b	0.7828±0.0077^b	0.281	0.0001	0.838
EE (kJ/min/mouse)	0.0308±0.00079	0.0339±0.0012	0.0321±0.0014	0.0340±0.0013	0.0367±0.0017	0.369±0.00153	0.001	0.104	0.685
EE_BW (kJ/min)^¥,	0.0315±1.57E-3	0.0332±1.76E-3	0.032±1.13E-4	0.0370±0.0019	0.0346±2.36E-3	0.0349±1.54E-3	0.022	0.927	0.958
EE_FFM (kJ/min)^$	0.033±2.06E-3	0.032±1.17E-3	0.031±1.32E-3	0.033±2.06E-3	0.032±1.73E-3	0.031±1.32E-3	0.150	0.289	0.856
EE_ORGAN (kJ/min)⁺	0.0299±1.11E-3^a	0.0341±1.19E-3^a	0.032±1.14E-3^a	0.036±2.18E-3^a	0.034±2.09E-3^a	0.035±1.32E-3^a	0.026	0.699	0.614
Fed
RQ	0.993±0.014	0.979±0.0042	0.980±0.0085	0.986±0.011	0.979±0.0065	0.972±0.0089	0.491	0.361	0.960
RQ_MEI ^α	0.997±0.010	0.977±0.011	0.983±0.009	0.982±0.009	0.971±0.014	0.974±0.008	0.219	0.284	0.918
EE (kJ/min/mouse)	0.0386±0.0013	0.0399±0.0012	0.0388±0.000703	0.0403±0.0013	0.0462±0.00078	0.0427±0.0013	0.001	0.086	0.311
EE_BW (kJ/min)^¥,	0.039±1.39E-3	0.039±1.56E-3	0.038±1.00E-4	0.044±1.33E-3	0.043±1.64E-3	0.040±1.07E-3	0.028	0.343	0.236
EE_FFM (kJ/min)^$	0.039±1.93E03	0.039±1.62E-3	0.038±1.24E-3	0.045±1.46E-3^a	0.042±1.64E-3^a	0.039±1.11E-3^b	0.170	0.074	0.298
EE_ORGAN (kJ/min)⁺	0.041±1.31E-3^a	0.040±1.20E-3^a	0.039±7.60E-4^a	0.045±1.65E-3^a	0.043±8.15E-4^a	0.041±6.69E-4^a	0.035	0.255	0.061

MEI, metabolizable energy intake; BW, body weight; FFM, fat-free mass; ORGAN, crude organ mass (sum of liver, kidney, heart, and brain mass); EE is expressed as EE kJ/min/mouse (kJ per min per mouse) and EE_{BW, FFM, ORGAN} (kJ/min normalized by BW, FFM, and ORGAN).

Data are presented as means ± SEM unless otherwise indicated; superscript letters that differ indicate differences between ages within temperature and feed period, Bonferroni corrected P values provided in table;

^{α, ¥, $,+}

values are presented as least square mean ± SEM, adjusted for MEI, BW, FFM, and ORGAN, respectively.

Table 4. Energy expenditure and respiratory quotient in ShcKO and wild-type (WT) mice housed at 12°C.1 .

Table 4. Energy expenditure and respiratory quotient in ShcKO and wild-type (WT) mice housed at 12°C.¹ .