Table 1. Demographic summary including cognitive features for Alzheimer’s disease patients and for a group of elderly controls.

		Control (N = 26)	Alzheimer’s Disease (N = 43)	Very mild Alzheimer’s disease (N = 21)	Mild Alzheimer’s disease (N = 22)
General Demographics	Gender, M:F	11∶15	26∶17	13∶8	13∶9
	Age at imaging, years	68 (6)	70 (6)	72 (5)	69 (6)
Global Cognition	MMSE/30	29.1 (0.8)	23.7 (3.6)**	25.9 (1.6)**	21.7 (3.9)**∧
	ACE-R/100	94.6 (3.0)	71.5 (11.9)**	81.4 (4.0)**	62.1 (8.8)**∧
ACE-R Subscores	Attention & Orientation/18	17.9 (0.3)	15.4 (2.7)**	17.0 (1.4)*	13.9 (2.8)**∧
	Memory/26	24.5 (1.9)	10.9 (4.3)**	13.7 (4.1)**	8.2 (2.4)**∧
	Fluency/14	12.1 (1.7)	8.3 (3.2)**	10.6 (1.9)*	6.2 (2.6)**∧
	Language/26	24.9 (0.9)	23.0 (2.6)**	24.6 (1.2)	21.5 (2.7)**∧
	Visuospatial/16	15.4 (0.9)	13.7 (2.8)**	15.1 (1.2)	12.3 (3.1)**∧

Disease severity (as measured by ACE-R) enabled a median split of the patient cohort into very mild and mild Alzheimer’s disease subgroups.

Where appropriate, group values are given as mean (SD).

MMSE/30 = Mini-mental state examination score out of 30-point total; ACE-R/100 = Addenbrooke’s cognitive examination-revised score out of 100-point total.

Wilcoxon rank-sum significance levels: *P<0.01 (Alzheimer’s disease worse than controls, two-tailed); **P<0.05 (Alzheimer’s disease worse than controls, two-tailed, Bonferroni-corrected on n = 28 tests); ∧P<0.05 (Mild worse than very mild Alzheimer’s disease, two-tailed, Bonferroni-corrected on n = 28).