Table 4. DTI group comparisons across disease stages and linear dependence on global cognition for all patients in the splenium.

Splenium	Cross-sectional			ACE-R Linear Dependence (N = 43)
	Very mild Alzheimer’s (N = 21) vs. Control (N = 26)	Mild Alzheimer’s (N = 22) vs. Control (N = 26)	Mild Alzheimer’s (N = 22) vs. Very mild Alzheimer’s (N = 21)
λ1	2.62*	1.19	1.54	0.15
RD	2.13§	3.07**	−0.89	−0.40**
MD	3.01**	2.74*	0.21	−0.21
FA	−1.27	−2.85*	1.4	0.44**

Group results are given as Wilcoxon rank-sum Z-statistic; statistical dependencies are given as Pearson correlation coefficient with 41 degrees of freedom.

Significance levels: ^§0.01<P<0.05 (Alzheimer’s disease worse than controls, two-tailed); *P<0.01 (Alzheimer’s disease worse than controls, two-tailed); **P<0.05 (Alzheimer’s disease worse than controls, two-tailed, Bonferroni-corrected on n = 24; or DTI measure correlated with Alzheimer’s disease cognitive status, two-tailed, Bonferroni-corrected on n = 12).